一、粉粒原料的灭菌技术含水量较少的粉粒原料,其传热性能差,微生物特别是孢子也不因干热而简单化地死绝,因此,加热灭菌而不损伤物料的质量是很困难的。非加热灭菌法则安全性和灭菌效果等也各有问题。 1.非加热灭菌法: (1)药剂灭菌法①气体灭菌法:环氧乙烷和环氧丙烷对革兰氏阳性菌、革兰氏阴性菌、孢子、真菌等微生物均有效。但气体灭菌剂毒性较强,且可与原料中的无机盐结合生成新的化合物 First, the powder material sterilization technology Less moisture content of the powder raw materials, the heat transfer performance is poor, especially the spores of microorganisms are not due to dry heat and simplistic death, therefore, heat sterilization without damaging the material Quality is very difficult. Non-heating sterilization safety rules and sterilization also have their own problems. 1. Non-heating sterilization method: (1) Pharmacy sterilization method ① gas sterilization method: Ethylene oxide and propylene oxide on Gram-positive bacteria, Gram-negative bacteria, spores, fungi and other microorganisms are effective. But the gas sterilant toxicity, and inorganic salts can be combined with raw materials to generate new compounds