造血干/祖细胞在细胞因子联合应用条件下,经体外扩增后其功能活性往往受到损伤,而一些研究表明造血基质细胞存在时,可促进或维持体外扩增造血细胞的功能活性,其作用的分子机制目前也已开始研究。基质细胞在造血细胞体外扩增中的作用及其分子机制的阐明,将推动造血细胞体外扩增技术研究及应用的进一步深入。 Hematopoietic stem / progenitor cells are often damaged after in vitro expansion under the condition of cytokine combined application. However, some studies show that when hematopoietic stem cells exist, they can promote or maintain the functional activity of expanded hematopoietic cells in vitro. The molecular mechanism has now begun to study. The role of stromal cells in the expansion of hematopoietic cells in vitro and elucidation of their molecular mechanisms will further promote the research and application of hematopoietic cell expansion in vitro.