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A simple and efficient procedure was developed for the synthesis of 11H(2H)-4-oxothiophene[3’,4’:6,5]pyrido[3,2-a]azulene-10-carboxylates(3) in moderate to good yields via the Gewald reaction of ethyl 1-cyanoacetyl-2-methoxyazulene-3-carboxylate(1) with carbonyl compounds(2) and elemental sulfur utilizing imidazole as catalyst.This reaction provides a new procedure for synthesis of pyridinone-fused azulenes.
A simple and efficient procedure was developed for the synthesis of 11H (2H) -4-oxothiophene [3 ’, 4’: 6,5] pyrido [3,2-a] azulene-10-carboxylates The via via the Gewald reaction of ethyl 1-cyanoacetyl-2-methoxyazulene-3-carboxylate (1) with carbonyl compounds (2) and elemental sulfur utilizing imidazole as catalyst. His reaction provides a new procedure for synthesis of pyridinone-fused azulenes.