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文章对二维红外光谱的历史、实验设备、方法原理、具体应用进行了简要的介绍,并对它的前景进行了展望.二维红外光谱是一种通过多束超快(10-15s(1fs)—10-12s(1ps)、中红外(400—4000cm-1)激光对分子的化学键的振动模式进行顺序激发,从而获得关于分子动态及静态结构信息的方法.它的原理非常类似于二维核磁共振,但要快上大约6个数量级.现在它已经开始被应用于研究平衡态下快速的分子变化,分子间相互作用(如氢键,偶极-偶极相互作用等)在常温液体里的动态变化,水氢键网络的演变过程,小分子、多肽和蛋白的静态或瞬间结构变化.
The article briefly introduces the history, experimental equipment, method principle and application of two-dimensional infrared spectroscopy, and gives a prospect of its future.The two-dimensional infrared spectroscopy is a multi-beam ultrafast (10-15s ) -10-12s (1ps) and mid-infrared (400-4000cm-1) lasers to sequentially excite the molecular vibrational modes of chemical bonds to obtain information about the dynamic and static structure of molecules. The principle is very similar to that of two-dimensional NMR, but it is about six orders of magnitude faster. It has now begun to be used to study rapid molecular changes in equilibrium. Intermolecular interactions (such as hydrogen bonding, dipole-dipole interactions, etc.) , The evolution of water-hydrogen bond networks, the static or transient structural changes of small molecules, peptides and proteins.