论文部分内容阅读
目的 探讨系统性红斑狼疮 (SLE)合并妊娠后患者与胎儿可能发生的不良情况及应该采取的措施。方法 分析 3例SLE合并妊娠患者与胎儿的临床表现、治疗原则和预后 ,并复习有关文献。结果 3例SLE合并妊娠患者中 2例早产 ,但胎儿均存活 (分别为 37周与 31周行剖宫产 ) ,另 1例 2 6周时并发狼疮肾病与狼疮脑病 ,于羊膜腔内注射利凡诺 (药物终止妊娠 ) ,随后顺产 1死婴。成活的 2例新生儿 (男女各 1 )分别为ANA(+)与SSA(+)。 3例患者在终止妊娠时均加大皮质激素的用量 ,其中 2例加用环磷酰胺。结论 SLE合并妊娠增加了患者的合并症和危险性 ,并使胎儿早产率及致死率增高 ;合并重要并发症 (如脑病 )的SLE患者应终止妊娠 ;无论以何种方式分娩出胎儿 ,均应对生产前后的SLE患者加强治疗
Objective To investigate the possible adverse events of patients and fetuses after systemic lupus erythematosus (SLE) combined with pregnancy and the measures to be taken. Methods The clinical manifestations, treatment principles and prognosis of 3 patients with SLE complicated with pregnancy and fetus were analyzed. The related literatures were reviewed. Results Two of the three patients with SLE complicated with pregnancy were born prematurely, but the fetuses survived (cesarean section was 37 weeks and 31 weeks, respectively) and the other 1 case received lupus nephropathy and lupus encephalopathy at 26 weeks. Fannuo (drug termination of pregnancy), followed by 1 dead baby. Two newborns (one male and one female) survived were ANA (+) and SSA (+), respectively. Three patients in the termination of pregnancy were increased corticosteroid dosage, of which 2 cases plus cyclophosphamide. Conclusions SLE combined with pregnancy increases the patient’s comorbidities and risks and increases fetal preterm delivery and lethality. Patients with SLE complicated by important complications such as encephalopathy should terminate their pregnancy. Whatever method is used to deliver the fetus, SLE patients before and after production to strengthen treatment