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最近的资料,着重地指出了β—受体在调节胰岛素分泌功能的重要性。然而长期服用β阻断剂,是否也引起葡萄糖代谢的失常呢?因而进行了下面的观察。40例高压患者服用心得安(160—320毫克/天)6个月后,其中7例已发展为明显的糖尿病,另外16例,经常按规定作葡萄糖耐量试验,表明出现药物性糖尿病。停用心得安后,明显的糖尿病患者,胰岛素用量逐渐减少,最后完全痊愈。16例药物性糖尿病患者,其中的9例,3—6个月之内,糖耐量试验也恢复到正常。在心得安治疗过程中,明显的糖尿病和药物性糖尿病患者,胰岛素血中含量分别是
Recent data have highlighted the importance of beta-receptors in regulating insulin secretion. However, long-term use of beta blockers, also caused glucose metabolism disorders? Therefore, the following observations. Of the 40 hypertensive patients taking propranolol (160-320 mg / day) for 6 months, 7 of them developed significant diabetes and the other 16 were often given glucose tolerance tests as prescribed, indicating drug-induced diabetes. After the suspension of the experience of security, patients with obvious diabetes, insulin dosage gradually reduced, and finally fully recovered. 16 patients with drug-induced diabetes, of which 9 cases, 3-6 months, glucose tolerance test returned to normal. In peace of mind treatment process, the obvious diabetes and drug-induced diabetes, insulin blood levels were