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许多药物都是经口服而达到效果的,影响口服吸收的因素很多,本文谈谈胃空速率对口服药物吸收的影响。胃空速率是单位时间内胃内容物向小肠排出的量,由于胃的吸收表面积较小,且药物在胃内滞留时间短,在胃吸收之前就流入小肠,所以许多药物在胃内吸收量很少,只有一些弱酸性药物在胃中吸收较多。人的小肠长数米,直径4cm,除具环状皱折和大量突起的绒毛和徽绒毛,可供吸收面积达200cm~2,远远大于胃外,还有蠕动快、血流量大、毛细血管有较大的孔道等有利于药物吸收的特点。因此,小肠是
Many drugs are achieved by oral and efficacy, there are many factors that affect oral absorption, this article talk about gastric emptying rate on the absorption of oral drugs. The gastric empty rate is the amount of gastric contents excreted into the small intestine per unit of time. Because the gastric absorption surface area is small and the drug stays in the stomach for a short time, it flows into the small intestine before absorption into the stomach, so many drugs absorb in the stomach very much Less, only some weakly acidic drugs absorb more in the stomach. Human small intestine length of several meters, diameter 4cm, in addition to ring wrinkles and a large number of protruding fluff and emblem fluff, available for the absorption area of 200cm ~ 2, far greater than the stomach, as well as fast peristalsis, blood flow, capillary Blood vessels have larger channels and other characteristics conducive to drug absorption. Therefore, the small intestine is