With the development of networked manufacturing, it is more and more imminent to solve prob-lems caused by inherent limitations of network technology, such as heterogeneity, collaboration collision, and decentralized control. This paper presents a framework for grid manufacturing, which neatly combines grid technology with the infrastructure of advanced manufacturing technology. The paper studies grid-oriented knowledge description and acquisition, and constructs a distributed knowledge grid model. The pa-per also deals with the protocol of node description in collaborative design, and describes a distributed col-laborative design model. The protocol and node technology leads to a collaborative production model for grid manufacturing. The framework for grid manufacturing offers an effective and feasible solution for the problems of networked manufacturing. The grid manufacturing will become an advanced distributed manu-facturing model and promote the development of advanced manufacturing technologies. With the development of networked manufacturing, it is more and more imminent to solve prob-lems caused by inherent limitations of network technology, such as heterogeneity, collaboration collision, and decentralized control. This paper presents a framework for grid manufacturing, which neatly combines grid technology with the infrastructure of advanced manufacturing technology. The paper studies grid-oriented knowledge description and acquisition, and constructs a distributed knowledge grid model. The pa-per again deals with the protocol of node description in collaborative design, and describes a distributed col- The protocol and node technology leads to a collaborative production model for grid manufacturing. The framework for grid manufacturing offers an effective and feasible solution for the problems of networked manufacturing. The grid manufacturing will become an advanced distributed manu-facturing model and promote the development of advanced manufacturi ng technologies.