【摘 要】
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Wntβ-catenin途径是Wnt中一条重要的信号转导途径,它与许多恶性肿瘤的发生、发展密切相关。已明确c-myc、cyclinD1等是此途径下游的靶基因,最近发现造血系统肿瘤中也存在Wnt
【机 构】
：
中南大学湘雅二医院血液科 410011长沙
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Wntβ-catenin途径是Wnt中一条重要的信号转导途径,它与许多恶性肿瘤的发生、发展密切相关。已明确c-myc、cyclinD1等是此途径下游的靶基因,最近发现造血系统肿瘤中也存在Wntβ-catenin途径异常,β-catenin蛋白质在造血系统肿瘤中高表达并且还可能上调cox2基因。本文就Wntβ-catenin信号转导途径及其在白血病中的作用作一综述,希望能为白血病的治疗提供新的方向。
Wntβ-catenin pathway is an important signal transduction pathway in Wnt, which is closely related to the occurrence and development of many malignant tumors. It has been clear that c-myc and cyclinD1 are downstream targets of this pathway. Recently, there is also a Wntβ-catenin pathway abnormality in hematopoietic tumors. The β-catenin protein is highly expressed in hematopoietic tumors and may up-regulate the cox2 gene. This article reviewed the Wntβ-catenin signaling pathway and its role in leukemia, hoping to provide a new direction for the treatment of leukemia.
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