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目的探讨胎儿纤维连接蛋白(f FN)评价先兆早产孕妇应用抗生素的临床疗效。方法选取2014年6月至2015年3月先兆早产孕妇64例,将其按随机数字表法分为对照组与观察组,各32例,对照组孕妇单用硫酸镁治疗,观察组孕妇在对照组基础上联合使用抗生素治疗,比较两组孕妇治疗后药物起效时间、保胎成功率、C-反应蛋白(CRP)异常率及f FN阳性率比较。结果观察组孕妇药物起效时间明显短于对照组,保胎成功率高于对照组,差异均有统计学意义(均P<0.05);治疗前,两组孕妇的CRP异常率、f FN阳性率比较,差异无统计学意义(P>0.05);治疗后,观察组孕妇明显低于对照组,差异有统计学意义(P<0.05)。结论 f FN作为判别抗生素治疗先兆早产的效果的临床指标指向性好,可作为常规检查积极推广。
Objective To investigate the clinical effect of fetus fibronectin (f FN) on the application of antibiotics in pregnant women with threatened preterm labor. Methods Sixty-four pregnant women with threatened preterm labor were selected from June 2014 to March 2015. They were divided into control group and observation group according to random number table method, 32 cases in each group. Pregnant women in the control group were treated with magnesium sulfate alone, Group based on the combination of antibiotic treatment, the two groups of pregnant women after treatment onset time, miscarriage success rate, C-reactive protein (CRP) abnormal rate and f FN positive rate comparison. Results The onset time of drug in observation group was significantly shorter than that in control group, and the success rate of miscarriage was higher than that in control group (all P <0.05). Before treatment, the abnormal rate of CRP and f FN were positive in both groups The difference was not statistically significant (P> 0.05). After treatment, the pregnant women in the observation group were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion f FN as a discriminant antibiotic treatment of threatened preterm delivery clinical indicators of good direction, can be actively promoted as a routine examination.