This paper addresses the change of the river-lake relationship in the Huai River and its causes due to environmental change and human activities. A preliminary analysis is made from three aspects: (1) the natural geographical change particularly captured by the Yellow River, (2) water conservancy project construction, and (3) socioeconomic development in the Huai River Basin. Key problems of changes in this river-lake relationship and the Huai River flood control are tackled, involving flood control and disaster alleviation ability of the Basin, engineering and non-engineering measurements applied to flood control and disaster mitigation, and water governance for adaptive management. Research shows that the Huai River is a rather complex one due to its complex geography with a hybrid wet and dry climate zoon, and higher population density. With the alternation of the river-lake relationship and socioeconomic development in the region, new problems keep arising, imposing new requirements on its sustainable water management. Thus, understanding the Huai River is a long and gradually improving process. Its future planning should keep absorbing new achievements of science and technology development, employing new technologies and methods, and gradually deepening our understanding of its fundamental principles. Water governance and adaptive water management will be new challenges and opportunities for the Basin in its river system change and flood control. This paper addresses the change of the river-lake relationship in the Huai River and its causes due to environmental change and human activities. A preliminary analysis is made from three aspects: (1) the natural geographical change particularly captured by the Yellow River, ( 2) water conservancy project construction, and (3) socioeconomic development in the Huai River Basin. Key problems of changes in this river-lake relationship and the Huai River flood control are tackled, involving flood control and disaster alleviation ability of the Basin, engineering and non-engineering measurements applied to flood control and disaster mitigation, and water governance for adaptive management. Research shows that the Huai River is a rather complex one due to its complex geography with a hybrid wet and dry climate zoon, and higher population density. With the alternation of the river-lake relationship and socioeconomic development in the region, new problems keep arising, imposing new requirement Thus, understanding the Huai River is a long and gradually improving process. Its future planning should keep absorbing new achievements of science and technology development, employing new technologies and methods, and gradually deepening our understanding of its fundamental principles. . Water governance and adaptive water management will be new challenges and opportunities for the Basin in its river system change and flood control.