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目的评价实时动态血糖监测系统(Guardian RT CGMS)与持续皮下胰岛素输注(CSII)联合应用对T2DM患者血糖控制的影响。方法 18例T2DM患者佩戴Guardian RT CGMS连续3d,并于监测的第2天给予CSII治疗,根据实时血糖情况调整胰岛素用量。结果各时段血糖、平均血糖及血糖波动幅度均较治疗前显著下降(P均<0.01);高血糖、低血糖报警次数及持续时间均较治疗前显著减少。结论 Guardian RT CGMS能及时显示血糖变化值,反映血糖变化趋势,以此指导CSII中胰岛素的应用,可平稳有效控制血糖,预防血糖大幅度波动和低血糖的发生。
Objective To evaluate the effect of combined use of Guardian RT CGMS and continuous subcutaneous insulin infusion (CSII) on glycemic control in patients with T2DM. Methods 18 cases of T2DM patients were treated with Guardian RT CGMS for 3d consecutive days and treated with CSII on the second day of monitoring. The dosage of insulin was adjusted according to the real-time blood glucose level. Results The blood glucose, mean blood glucose and blood glucose fluctuation amplitude in each time period were significantly lower than those before treatment (all P <0.01). The number and duration of hyperglycemia and hypoglycemia alarm were significantly lower than those before treatment. Conclusion Guardian RT CGMS can display the change of blood glucose in time and reflect the change trend of blood glucose, so as to guide the application of insulin in CSII. It can control the blood sugar smoothly and effectively, prevent the fluctuation of blood sugar and the occurrence of hypoglycemia.