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目的:分析度洛西汀所致不良反应的发生情况及临床特点,为合理用药提供参考。方法:检索Pubmed,CNKI,VIP数据库中收载度洛西汀所致不良反应文献进行统计分析,检索时间为2004-2014年7月。结果:共检索41例次不良反应报道,以女性为主(32例,78.0%),年龄分布以40~60岁多见(21例,51.2%)。度洛西汀所致不良反应累及的器官或系统较多,以肝胆系统损害最为多见(12例,29.3%),其余多见为神经和精神系统损害、内分泌紊乱、心血管系统损害等。结论:临床合理使用度洛西汀的同时,临床应警惕度洛西汀不良反应,加强监测以实现临床用药安全有效。
Objective: To analyze the occurrence and clinical characteristics of duloxetine-induced adverse reactions and provide reference for rational drug use. Methods: We searched Pubmed, CNKI and VIP databases for statistical analysis of adverse drug reactions caused by duloxetine. The retrieval time was from 2004 to July 2014. Results: A total of 41 adverse reactions were reported, mainly female (32 cases, 78.0%). The distribution of age was more common in 40-60 years (21 cases, 51.2%). Duloxetine caused by adverse reactions involving organs or systems more, the most common damage to the hepatobiliary system (12 cases, 29.3%), the rest more common for the nervous and mental system damage, endocrine disorders, cardiovascular system damage. Conclusion: While clinical use of duloxetine should be vigilant, adverse effects of duloxetine should be observed clinically and monitoring should be strengthened in order to achieve safe and effective clinical medication.