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以取代2-溴吡啶和羟基苯硼酸为原料,经Suzuki偶联和亲核取代两步反应合成了9个未见报道的含取代2-苯基吡啶基团的甲氧基氨基甲酸酯类化合物,其结构均经红外光谱、核磁共振氢谱及质谱(ESI-MS)表征。初步生物活性测定结果表明:在500 mg/L下,部分化合物对朱砂叶螨Tetranychus cinnabarinus的致死率达100%,具有作为杀螨剂先导结构的潜力。
Nine unsubstituted 2-phenylpyridyl-containing methoxycarbamates were synthesized by two steps of Suzuki coupling and nucleophilic substitution using 2-bromopyridine and hydroxybenzeneboronic acid as starting materials. Their structures were characterized by IR, 1H-NMR and ESI-MS. The results of preliminary bioassay showed that the lethality of some compounds to Tetranychus cinnabarinus reached 100% at 500 mg / L, which showed the potential as the leading structure of acaricide.