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关于是否应调低ALT参考上限的争论已持续了近20年,然而,参考区间与诊疗决策阈值的概念、建立方法及应用范围是不同的,现对此进行辨析与相关研究回顾,以帮助更好地应用参考区间与诊疗决策阈值。“,”The debate about whether the upper limit of normal for ALT should be lowered has been going on for nearly 20 years. However, the concept, the establishment method, and the application scope of reference interval are different from those of the clinical diagnosis and treatment decision threshold. We will differentiate the two concepts and review the related publications to help clinicians better apply the reference interval and the decision threshold for disease diagnosis and treatment.