Expression of Histone H2AX Phosphorylation and Its Potential to Modulate Adriamycin Resistance in K5

来源 :Journal of Huazhong University of Science and Technology(Med | 被引量 : 0次 | 上传用户：li5815736

【摘要】

：

DNA repair processes play a role in the development of drug resistance which represents a huge obstacle to leukemia chemotherapy. Histone H2AX phosphorylation (

【作者】

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周芬梅恒吴秋玲金润铭

【机构】

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DepartmentofPediatrics,DepartmentofHematology

【出处】

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Journal of Huazhong University of Science and Technology(Med

【发表日期】

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2011年2期

【关键词】

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细胞株阿霉素磷酸化组蛋白 DNA双链断裂 K562细胞单细胞凝胶电泳抗性 γH2AX DNA DSBs LY249002 K562/A02 ce

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DNA repair processes play a role in the development of drug resistance which represents a huge obstacle to leukemia chemotherapy. Histone H2AX phosphorylation (ser139) (γH2AX) occurs rapidly at the onset of DNA double strand break (DSB) and is critical to

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Expression of Histone H2AX Phosphorylation and Its Potential to Modulate Adriamycin Resistance in K5

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