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目的探讨大剂量他汀类药物在急性心肌梗死溶栓前用药的预后。方法将62例急性心肌梗死患者随机分为常规治疗组和强化治疗组,常规治疗组:氟伐他汀40mg/次,1次/晚;强化组:氟伐他汀80mg/次,1次/晚,1周后改为40 mg/次,1次/晚。观察两组患者治疗后出现的心脑血管终点事件。结果强化治疗组出现心脑血管终点事件发生率明显低于常规组,差异有统计学意义(P<0.05);治疗后强化治疗组较常规治疗组血脂下降明显,差异有统计学意义(P<0.05)。结论大剂量他汀类药物在急性心肌梗死发病后早期应用能有效降低心脑血管事件的发生率,延缓并阻止动脉硬化的发展,安全性及耐受性均非常良好,值得在临床上推广。
Objective To investigate the prognosis of high-dose statins before thrombolysis in patients with acute myocardial infarction. Methods 62 patients with acute myocardial infarction were randomly divided into routine treatment group and intensive treatment group, conventional treatment group: fluvastatin 40mg / time, once a night; Intensive group: fluvastatin 80mg / time, once / night, 1 week later changed to 40 mg / time, 1 time / night. The two groups of patients were observed after treatment of cardiovascular end points. Results The incidence of cardio-cerebrovascular end points in the intensive treatment group was significantly lower than that in the conventional group (P <0.05). The levels of serum lipids in the intensive treatment group were significantly lower than those in the conventional treatment group (P < 0.05). Conclusions High-dose statins can reduce the incidence of cardiovascular and cerebrovascular events and delay and prevent the development of atherosclerosis early after acute myocardial infarction. The safety and tolerability of high-dose statins are very good and worthy of clinical application.