Wegener氏肉芽肿是一种特殊的坏死性肉芽肿,有呼吸道脉管炎、病灶性坏死性肾小球肾炎及全身性脉管炎等。作者观察分析了52例,其中31例有鼻部损害,单独鼻部受累者9例、伴有肺部损害者4例、伴有肾脏损害者2例、伴有声门下梗阻者5例、伴有肺脏和肾脏损害者7例。其他病例单独肺脏损害者13例、肺脏、肾脏损害者5例。亦有累及皮肤、眼眶者。鼻部损害多呈早期症状,表现为感冒或鼻窦炎、鼻分泌物增多呈清涕、褐色或脓性,很少鼻衄。典型的临床表现为中年患者有持续性鼻堵而无其他鼻病史。Wegener氏肉芽肿的早期鼻内表现仅呈现一般广泛的粘膜肿胀,无组 Wegener’s granulomatosis is a special type of necrotizing granuloma with respiratory vasculitis, focal necrotizing glomerulonephritis, and systemic vasculitis. The authors observed and analyzed 52 cases, of which 31 cases had nasal damage, 9 cases of individual nasal involvement, 4 cases of lung damage, 2 cases of renal damage, 5 cases of subglottic obstruction, Lung and kidney damage in 7 cases. Other cases of lung damage alone in 13 cases, lung, kidney damage in 5 cases. Also involving the skin, orbit. Nasal lesions were mostly early symptoms, manifested as cold or sinusitis, increased nasal discharge was clear tears, brown or purulent, rarely rhinitis. A typical clinical manifestation is persistent nasal blocking in middle-aged patients without any history of other nasal diseases. The early intranasal appearance of Wegener’s granulomatosis showed only a wide range of mucosal swelling with no group