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白血病抑制因子(LIF)是一种45～56kDa分泌性糖蛋白,它诱导M_1粒细胞白血病细胞系的分化并抑制该细胞系的增殖。Stewart等报道在妊娠第4～5天的小鼠子宫内胰腺体有LIFmRNA的大量表达。为进一步了解LIF在生殖生理的意义,本文检查了LIF对鼠子宫内膜上皮细胞蛋白质合成及胚泡发育的影响。
Leukemia inhibitory factor (LIF) is a 45- 56 kDa secreted glycoprotein that induces the differentiation of M 1 myeloid leukemia cell lines and inhibits the proliferation of this cell line. Stewart et al. Reported that large numbers of LIF mRNA were expressed in the uterus pancreatic glands of mice on days 4 to 5 of pregnancy. To further understand the significance of LIF in reproductive physiology, we examined the effects of LIF on protein synthesis and blastocyst development in murine endometrial epithelial cells.