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目的 :探讨东北地区汉族人HLA DRB1等位基因与慢性肾功能衰竭的遗传关联。方法 :应用聚合酶链反应———序列特异性引物 (PCR SSP)分型技术 ,对 44例慢性肾功能衰竭患者以及 336例正常人HLA DRB1等位基因进行分析。结果 :慢性肾功能衰竭患者DRB1 0 70 1的基因频率较正常对照组明显增高 ,且有非常显著性差异 (P <0 0 0 1,RR =4 76 ,Pc <0 0 1) ;患者组的DRB1 12 0 1、12等位基因频率明显高于正常对照组 ,差异有显著性 (P <0 0 0 5 ,RR =6 83 ,Pc <0 0 5 ) ;结论 :DRB1 0 70 1和DRB1 12 0 1 12 0 2基因与慢性肾功能衰竭有一定的关联 ,慢性肾功能衰竭患者与正常人之间存在着免疫遗传异质性的差异。或者可以提示携带DRB1 0 70 1和RDB1 12 0 1 12 0 2基因肾病患者 ,预后较差 ,易发展成为不可逆的慢性肾功能衰竭。
Objective: To investigate the genetic association between HLA DRB1 alleles and chronic renal failure in northeastern Han Chinese. Methods: HLA-DRB1 alleles were analyzed in 44 patients with chronic renal failure and 336 normal controls by polymerase chain reaction-sequence-specific primers (PCR SSP). Results: The frequency of DRB1 0 70 1 gene in patients with chronic renal failure was significantly higher than that in the normal controls (P <0.01, RR = 4 76, Pc <0.01) DRB1 12 0 1, 12 allele frequency was significantly higher than the normal control group, the difference was significant (P <0 0 0 5, RR = 6 83, Pc <0 0 5); Conclusion: DRB1 0 70 1 and DRB1 12 0 1 12 0 2 gene and chronic renal failure have a certain relationship, there is a difference in immune genetic heterogeneity between patients with chronic renal failure and normal. Or may be prompted to carry DRB1 0 701 and RDB1 12 0 1 12 0 2 gene nephropathy patients, the prognosis is poor, easy to develop into irreversible chronic renal failure.