线粒体是细胞的能量工厂,而线粒体基因表达受多种内外因素的影响,包括核基因的表达、激素、缺氧、氧化应激、辐射、ATP浓度及一些化学因素等。在肿瘤细胞中,线粒体基因表达总体上是上调的,这可能是线粒体对肿瘤细胞高能量需求的一种代偿,亦可能是通过抑制细胞凋亡使肿瘤细胞过度增殖。 Mitochondria are cellular energy factories, and mitochondrial gene expression is affected by many internal and external factors, including nuclear gene expression, hormones, hypoxia, oxidative stress, radiation, ATP concentration and some chemical factors. In tumor cells, mitochondrial gene expression is generally upregulated, which may be mitochondrial high energy needs of tumor cells in a compensatory manner, may also be by inhibiting apoptosis of tumor cells over-proliferation.