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本文研究在体外细胞培养系统中直接加入雌二醇(E_2)对脾细胞和胸腺细胞的作用,发现高剂量(≥5μg/ml)的E_2可直接抑制脾细胞对ConA诱导的增殖反应;但在胸腺细胞的实验中,无论低或高剂量(10~(-2)ng/ml～20μg/ml)的E_2均未发现它对ConA诱导的增殖反应产生明显影响。表明E_2在体外对脾细胞和胸腺细胞的作用存在差异。
In this study, we investigated the effects of estradiol (E 2) directly on the proliferation of splenocytes and thymocytes in in vitro cell culture system. It was found that high dose (≥5 μg / ml) of E 2 could directly inhibit the proliferation of splenocytes induced by Con A; however, In the thymocyte experiment, no significant effect on the proliferation response induced by ConA was found in E_2, both low and high dose (10-2 ng / ml ~ 20μg / ml). E_2 in vitro showed that there are differences in the role of spleen cells and thymocytes.