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目的 探讨柯萨奇 B组病毒 (Cox B)的感染情况 ,了解其发病规律。方法 采用酶捕捉法 ,对疑似 Cox B感染的76 6例患者进行了 Cox B- Ig M、Cox B- Ig G检测及 Cox B1～ 6 型的血清学分型鉴定。全部病例均作血液细菌学培养、生化常规检验及类风湿因子试验 ,并对患者的临床表现及中药治疗进行了分析。结果 在 76 6例检样中测得 Cox B- Ig M阳性 6 6例 ,占总检病例的 8.6 %。对 6 6例 Cox B- Ig M阳性病例进行了 Cox B1～ 6 - Ig M分型试验 ,测得 Cox B1 3例 ,Cox B2 4例 ,Cox B32 9例 ,Cox B42 2例 ,Cox B5 4例 ,Cox B6 最低仅 1例 ,其中有 3例同时测得 Cox B3和 Cox B4抗体。在获得的第 2份患者血清中均测得 Cox B-Ig G抗体 ,其滴度 >1∶ 16或 1∶ 32。据此可证明为 Cox B感染。结论 小儿 Cox B病毒感染呈散发性发病 ,可见于小儿各年龄段 ;根据患儿临床表现 ,结合特异性 Cox B- Ig M检测 ,可以确诊 ;血清 Cox B- Ig M检测可供临床推广应用。
Objective To investigate the infection of Cox B virus and to understand its pathogenesis. Methods Sixty-six patients with suspected Cox B infection were assayed for Cox B-Ig M, Cox B-Ig G and Cox B1-6 serotypes by enzyme-capture method. All cases were for blood bacteriological culture, routine biochemical tests and rheumatoid factor test, and the clinical manifestations of patients and treatment of Chinese medicine were analyzed. Results Sixty-six Cox-Ig M positive samples were detected in 766 samples, accounting for 8.6% of the total samples. Cox B1 ~ 6 - Ig M typing tests were performed in 66 Cox B - M positive cases. Cox B1 was detected in 3 cases, Cox B2 in 4 cases, Cox B32 in 9 cases, Cox B42 in 2 cases and Cox B5 in 4 cases , Cox B6 was only 1 case in the lowest, of which 3 cases measured Cox B3 and Cox B4 antibodies at the same time. Cox B-Ig G antibodies were measured in the second patient sera obtained with titers> 1:16 or 1:32. According to this can prove to be Cox B infection. Conclusions Cox B virus infection in children is sporadic and can be found in all age groups. According to the clinical manifestations of children and combined with the specific Cox B-Ig M test, Cox B IgM can be diagnosed and used clinically.