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药物相互作用有对机体产生不利影响甚至损伤的,有通过有意协同而获益的。一般可分两类,药动学的相互作用和药效学的相互作用。前者包括药物吸收、分布、代谢和排泄方面的改变;后者包括由合并用药产生药效的对抗或协同,也包括一个药物改变另一个药物组织的敏感性或反应性。药动学的相互作用一、改变吸收药物在胃肠道吸收的改变,可减少药物的总吸收,降低疗效或延误吸收,影响效应(如急性止痛)迅速呈现,耽误吸收同样能延长药物效应,如用催眠剂,患者可因次日清晨体内过多残留药物而呈现宿醉。
Drug interactions have adverse effects on the body or even damage, there are benefits through deliberate synergy. Generally divided into two categories, pharmacokinetic interaction and pharmacodynamic interactions. The former includes changes in drug absorption, distribution, metabolism and excretion; the latter includes efficacy or synergy that results from the combination medication, as well as the sensitivity or responsiveness of one medication to another. Pharmacokinetic interaction First, change the absorption of drugs in the gastrointestinal tract changes in the absorption can reduce the total absorption of drugs to reduce the efficacy or delay in absorption, the impact of the effect (such as acute pain) quickly presented, delayed absorption can also extend the drug effect, If using hypnosis, the patient may hangover in the early morning after too much residual drug in the body.