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用跳台法和电迷宫法,观察双苯氟嗪(dipfluzine)对亚硝酸钠和戊巴比妥钠造成的小鼠记忆障碍的改善作用,双苯氟嗪可明显改善亚硝酸钠引起的小鼠记忆障碍和戊巴比妥钠造成的小鼠方向辨别的获得障碍,且有剂量关系,20和40mg·kg~(-1)双苯氟嗪使小鼠跳台错误次数和出现跳台错误动物的百分率均显著低于溶剂对照组.20 mg·kg~(-1)双苯氟嗪使小鼠在训练的d1和d2受到电刺激后的正确逃避反应数均显著高于溶剂对照组(P<0.05).双苯氟嗪改善亚硝酸钠引起的小鼠记忆障碍的作用与桂利嗪(cinnarizine)相似,在改善记忆的有效剂量(20mg·kg~(-1))下,双苯氟嗪还有抗小鼠急性脑缺氧作用,使断头后小鼠张口呼吸动作持续时间(32±s7s)显著长于溶剂对照组(20±s4s,P<0.01).
Using jumping table method and electrical maze method, we observed the effect of dipfluzine on the improvement of memory impairment induced by sodium nitrite and sodium pentobarbital in mice. Dipfluzine significantly improved the activity of sodium nitrite-induced mice Dysmnesia and pentobarbital sodium caused by the direction of the mice to identify barriers to access, and a dose-related, 20 and 40mg · kg -1 Dipfluzine so that the number of mice jumping error and the percentage of animals jumping error Were significantly lower than that of the solvent control group.The number of correct evasion reaction of the mice receiving 20 mg · kg -1 dipfluzine after electrical stimulation at d 1 and d 2 were significantly higher than those of the solvent control group ). Dipfluzine improves sodium nitrite-induced memory impairment in mice Similar to cinnarizine, diphenazine is also found to be effective in improving memory (20 mg · kg -1) With anti-acute cerebral hypoxia effect, the duration of mouth breathing (32 ± s7s) of mice after decapitation was significantly longer than that of the solvent control group (20 ± s4s, P <0.01).