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为了解新生儿乙型肝炎（乙肝）疫苗全程免疫后抗－HBs低应答者的再感染情况和转归，为免疫预防措施提供依据，选取乙肝疫苗全程免疫后抗-HBs低应答者28例进行长期血清流行病学随访．结果有12例（42．86％）仍是HBsAg、抗-HBs和抗-HBc三项全阴性，也未发现HBV感染指征；5例（17．86％）出现了单项抗-HBsS／N值≥10．0以上的应答；11例（36．4％）发生HBV感染，其中4例（36．4％）变为持续阳性者，有1例为HBsAg阳性可能仍属母婴阻断失败者。表明抗-HBs低应答是个暂时现象，多数有潜伏感染，但预后是好的．
In order to understand the re-infection status and prognosis of anti-HBs low responders after immunization of neonatal Hepatitis B (HB) vaccine and to provide evidence for immunoprophylaxis, we selected 28 patients with anti-HBs low responders after full vaccination of Hepatitis B vaccine Long-term serum epidemiological follow-up. Results 12 cases (42.86%) were still HBsAg, all-negative for anti-HBs and anti-HBc and no indication for HBV infection. A single anti-HBsS / N In 11 (36.4%) cases of HBV infection, 4 (36.4%) became persistent and 1 had HBsAg-positive and still failed maternal-infant blockage By. The low anti-HBs response is transient and most have latent infection, but the prognosis is good.