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目的:对党参超微粉与细粉中的有效成分党参炔苷在大鼠体内的药动学进行比较。方法:采用高效液相质谱(HPLC)法分别测定灌服两种样品的大鼠体内党参炔苷的血药浓度,通过DAS 2.0药动学软件处理数据,比较党参超微粉及其细粉在大鼠体内的药动学参数和相对生物利用度。结果:党参炔苷在大鼠体内的血药浓度-时间数据符合单室模型;Cmax分别为1.408,1.932μg·mL~(-1);tmax分别为1,1.5 h;t1/2分别为0.243,0.674 h;V分别为34.701,50.745 L;CL分别为5.281,3.779 L·h~(-1)。党参超微粉相对于细粉,其生物利用度提高了39.7%。结论:党参经超微粉碎后可促进其党参炔苷在大鼠体内的吸收,提高生物利用度。
Objective: To compare the pharmacokinetics of Codonoplanin in Codonopsis ultrafine powder and fine powder in rats. Methods: The concentrations of Cmax in rats fed with the two samples were determined by high performance liquid chromatography (HPLC). The data of DAP 2.0 pharmacokinetics software were used to compare the effects of Codonopsis pilosula micropowder Pharmacokinetic parameters and relative bioavailability in rats. Results: The concentration-time curve of CTP in rats was consistent with single-compartment model. The Cmax values were 1.408 and 1.932 μg · mL -1, tmax was 1 and 1.5 h respectively, and t1 / 2 was 0.243 , 0.674 h respectively; V were 34.701 and 50.745 L respectively; CL were 5.281 and 3.779 L · h -1, respectively. Codonopsis powder relative to the fine powder, the bioavailability increased by 39.7%. Conclusion: Codonopsis by ultrafine pulverization can promote the absorption of Codiphnin in rats and improve the bioavailability.