对照区青少年骨龄延迟率17.62%,为本底值。地方性氟中毒病区骨龄延迟率30.29%和49.25%,明显高于对照点,经改水的干预试验后骨龄延迟率下降至22.22%,接近对照点水平。表明影响青少年骨生长发育的因素主要存在于饮水中,饮水中高氟可能是主要因素,改水是有效的预防措施。 The control group of young skeletal age delay rate of 17.62%, as the background value. The skeletal-age retardation rates in endemic fluorosis area were 30.29% and 49.25%, respectively, which were significantly higher than those in the control sites. The delay of skeletal age decreased to 22.22% after the water-based intervention test, approaching the control level. That the main factors affecting bone growth and development in adolescents in drinking water, drinking water may be the main factor of high fluoride, water change is an effective preventive measure.