硝基喹啉-N-氧化物,通常采用几步反应合成,作者在研究2,4,6-三硝基甲苯(TNT)形成的硝基苄阴离子的反应活性过程中,发现一种由TNT和α,β-不饱和醛制备硝基喹啉-N-氧化物的简便方法。下面报道3-苯基-5,7-二硝基喹啉-N-氧化物的合成及晶体结构。 1 实验部分 1.1 合成 在25 mL平底烧瓶中,加入2.5 g TNT、1.5 g 3-苯基丙烯醛、20 mL无水甲醇。在水浴上加热使固体全部溶解后,滴加0.65 g哌啶。然后继续加热至出现回流。约6 min Nitroquinoline-N-oxide, usually using a few steps of reaction synthesis, the authors in the study of 2,4,6 - trinitrotoluene (TNT) formed by the reaction of nitrobenzene anion, found a TNT And α, β-unsaturated aldehyde nitroquinoline N-oxide prepared by a simple method. The synthesis and crystal structure of 3-phenyl-5,7-dinitroquinoline-N-oxide are reported below. 1 Experimental 1.1 Synthesis In a 25 mL flat-bottom flask, 2.5 g of TNT, 1.5 g of 3-phenylacrolein and 20 mL of anhydrous methanol are added. After heating in a water bath to dissolve all solids, 0.65 g piperidine was added dropwise. Then continue to heat to reflux. About 6 min