目的 :通过对一综合性教学医院 1991～ 1998年间所分离的 2 2 1株伤寒杆菌药敏结果进行分析 ,以观察其对各种抗生素的耐药率及其变迁。结果发现 ,伤寒杆菌耐药株占 5 1.5 8% ,其中对阿米卡星、氨苄西林、头孢哌酮、氯霉素、头孢唑啉、庆大霉素与环丙沙星的耐药率分别为 3.17% ,13.5 8% ,0 .45 % ,7.6 9% ,9.96 % ,18.82 %与 0 .90 % ;八年中除对头孢唑啉耐药率有逐渐下降趋势外 ,对其余各类抗生素的耐药率均无明显规律变化 OBJECTIVE: To analyze the drug susceptibility results of 2121 strains of Salmonella typhimurium isolated from a comprehensive teaching hospital from 1991 to 1998, and to observe their resistance rates to various antibiotics and their changes. The results showed that Salmonella typhi resistant strains accounted for 5 1.58%, of which amikacin, ampicillin, cefoperazone, chloramphenicol, cefazolin, gentamicin and ciprofloxacin resistance rates were Were 3.17%, 13.58%, 0.45%, 7.69%, 9.96%, 18.82% and 0.90%, respectively. In addition to the gradual decline in the rate of cefazolin resistance in eight years, the remaining types of antibiotics There was no obvious regular change of drug resistance rate