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目的：观察大鼠海马生长抑素（Ｓｏｍａｔｏｓｔａｔｉｎ，ＳＳ）阻断神经元在高压氧致惊厥中的变化。方法：应用原位杂交组织化学法。结果：大鼠氧惊厥时ＳＳ－ｍＲＮＡ阳性神经元在海马各区均有分布，且数目增多；而其余各组ＳＳ－ｍＲＮＡ阳性神经元多分布于海马ＣＡ４区。结论：海马内ＳＳ神经元在氧惊厥时可能通过对γ－氨基丁酸（ＧＡＢＡ）的抑制及释放ＳＳ兴奋海马的锥体细胞，发挥与兴奋性氨基酸相类似的作用而参与氧惊厥的发病机理。
Objective: To observe the change of neurons in the hippocampus induced by somatostatin (SS) in rats induced by hyperbaric oxygen. Methods: In situ hybridization histochemical method. Results: SS-mRNA positive neurons were distributed in hippocampus in rats with oxygen convulsion, and the number increased; while in other groups, SS-mRNA positive neurons were distributed in hippocampal CA4 area. CONCLUSIONS: SS neurons in hippocampus may participate in the pathogenesis of oxy-convulsions by inhibiting the activation of γ-aminobutyric acid (GABA) and releasing the SS-stimulated pyramidal cells of the hippocampus during oxygen-induced convulsion .