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目的观察药物预处理改善肺癌患者化疗所致呕吐的效果。方法选取肺癌患者124例,随机分为观察组与对照组各62例,观察组再随机分为A组与B组各31例。所有患者均接受常规化疗,对照组在出现严重不耐受现象后予昂丹司琼;观察组A组给予胃复安、麻仁软胶囊、苯海拉明及地塞米松联合治疗,B组仅予胃复安治疗。观察3组患者呕吐情况,评价治疗效果;对3组化疗前后体力情况进行评分。结果观察组A组控制有效率为90.3%,优于B组的74.42%(P<0.05);对照组控制有效率仅50.00%。A组、B组与对照组分别比较差异均有统计学意义(P<0.05)。3组化疗后体力评分均较化疗前降低,其中A、B两组降低程度大于对照组(P<0.05)。结论药物预处理对预防肺癌患者化疗所致呕吐,效果显著,有效改善患者体力状况,值得临床推广应用。
Objective To observe the effect of drug pretreatment on chemotherapy-induced vomiting in patients with lung cancer. Methods 124 patients with lung cancer were randomly divided into observation group and control group, 62 cases each. The observation group was randomly divided into A group and B group, 31 cases each. All patients received conventional chemotherapy, the control group in the event of severe intolerance to the ondansetron; observation group A group was given metoclopramide, Maren soft capsules, diphenhydramine and dexamethasone combination therapy, B group Only metoclopramide treatment. The vomiting of the three groups was observed to evaluate the therapeutic effect. The physical condition of the three groups before and after chemotherapy was scored. Results The effective rate of control in group A was 90.3%, which was significantly higher than that in group B (74.42%, P <0.05). The effective rate of control group was only 50.00%. The difference between group A, group B and control group was statistically significant (P <0.05). The physical scores of the three groups after chemotherapy were lower than those before chemotherapy, in which the reduction in group A and B was greater than that in the control group (P <0.05). Conclusion The drug pretreatment can prevent chemotherapy-induced vomiting in patients with lung cancer, and the effect is significant. It can effectively improve the physical condition of patients and is worthy of clinical application.