为考核肾综合征出血热地鼠肾细胞Ⅱ型灭活疫苗的安全性、免疫性及防病效果，对接种组７４９９人、对照组７２６１人进行系统观察。疫苗接种反应率在１２１％～８９２％之间，以弱反应为主。疫苗接种者在接种后２周，荧光抗体阳转３８５８％，中和抗体阳转率为６３３３％，疫苗接种一年后荧光抗体全部阴转，加强一年后抗体又有６７８６％阳转。经过两次流行高峰期前后，对疫苗接种人群血中荧光抗体进行检测，流行高峰期后（５３６％～１５２６％）高于流行高峰期前（４４６％～５０８％），且有阴性再次阳转的情况，证明有良好的特异性回忆反应。疫苗接种后４周年，对照组发病３例，接种组无一例发生，疫苗保护率为１００％。 In order to test the safety, immunity and disease control effect of type Ⅱ inactivated vaccine of hemorrhagic fever with renal syndrome in rats, 7499 inoculated group and 7261 in control group were observed systematically. Vaccination response rate was 1  21% ~ 8  92%, with weak response-based. Two weeks after inoculation, the positive rate of fluorescent antibody was 3858%, and the positive rate of neutralization antibody was 6333%. After one year of vaccination, all the fluorescent antibodies were negative, and one year later, there were 67% of antibodies. 86% Yang rotation. Fluorescent antibodies in the vaccinated population were detected before and after the two epidemic peak periods (536% -1526%) before the peak of the epidemic period (4.46% -5.08% ), And a negative case of the sun again to prove that there is a good specific memory response. Four weeks after vaccination, 3 cases were in control group, none in vaccination group. The vaccine protection rate was 100%.