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临床上常见的抗精神病药产生的药物副反应有锥体外系反应、药物性肝损伤、性功能障碍、闭经、粒细胞减少症、药物性皮炎、消化系统功能紊乱、体质量异常增加等。根据患者服用抗精神病药后毒副作用的临床表现,运用“有诸内必形诸外、司外揣内、取类比象、审症求因、以药测证”等中医临床认识模式,可以发现,在常规治疗过程中,抗精神病药作用于人体,根据体质和药物的不同,产生的不同副作用和毒性反应,但大致不离脾胃郁热、阳明热盛;热盛风动、津亏生风;痰湿内生、络脉瘀阻。对抗精神病药引起的药源性疾病辨证施治,在临床实践中取得了较为显著的疗效,治法以清热、泻下、补气、养阴、活血、化痰为主,其中养阴、活血具有特殊意义。
Clinical side effects of antipsychotic medications include extrapyramidal reactions, drug-induced liver injury, sexual dysfunction, amenorrhea, neutropenia, drug dermatitis, digestive system dysfunction, and abnormally increased body mass. According to the clinical manifestations of toxic and side effects of patients taking antipsychotics, the use of “clinical knowledge model of traditional Chinese medicine such as internal and external medicine, extra-specialized internal medicine, analogy, symptomatic evidence, and drug testing ”, etc., It can be found that in the course of conventional treatment, antipsychotic drugs act on the human body, depending on the physical and drug differences, resulting in different side effects and toxic reactions, but generally do not leave the spleen and stomach phlegm, Yangming heat Sheng; hot Sheng wind, Tianjin loss Wind; dampness endogenous, collateral vein resistance. Anti-psychotic drugs caused by drug-induced disease differentiation and treatment, in clinical practice has achieved a more significant effect, the law to heat, diarrhea, qi, Yin, blood circulation, phlegm-based, including Yin, blood Has special significance.