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目的:探讨氟尿嘧啶植入剂在进展期胃癌术中应用的价值。方法:回顾性分析手术治疗162例进展期胃癌患者的临床资料,其中98例患者术中应用氟尿嘧啶植入剂行腹腔化疗(腹腔化疗组)。其余64例患者未行腹腔化疗,设为对照组。结果:2组1年生存率皆为100%,腹腔化疗组2、3年生存分别为83.7%、73.5%,对照组分别为67.2%、57.8%,差异具有统计学意义,P<0.05。2组在胃肠减压时间、总住院时间、切口感染和吻合口漏等方面差异无统计学意义,P>0.05。结论:氟尿嘧啶植入剂术中化疗有助于提高进展期胃癌术后生存率,值得临床推广应用。
Objective: To investigate the value of fluorouracil implants in the treatment of advanced gastric cancer. Methods: The clinical data of 162 patients with advanced gastric cancer treated by surgery were retrospectively analyzed. Among them, 98 patients underwent intraperitoneal chemotherapy (intraperitoneal chemotherapy) with fluorouracil implants. The remaining 64 patients without intraperitoneal chemotherapy, as the control group. Results: The 1-year survival rate was 100% in both groups, and the 2-year and 3-year survival rates were 83.7% and 73.5% in the intraperitoneal chemotherapy group and 67.2% and 57.8% in the control group, respectively, with statistical significance, P <0.05.2 There was no significant difference in the time of gastrointestinal decompression, total length of hospital stay, incisional infection and anastomotic leakage (P> 0.05). Conclusion: Intraoperative chemotherapy with fluorouracil implant can help to improve the postoperative survival rate of advanced gastric cancer, which is worthy of clinical application.