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用分散聚合的方法制得单分散微米级聚苯乙烯微球(PS),以此聚苯乙烯微球作为种子,以邻苯二甲酸二丁酯为溶胀剂,苯乙烯为单体,二乙烯基苯为交联剂,甲苯为致孔剂,采用种子溶胀聚合的方法制得粒径分布较窄的多孔高交联的聚苯乙烯-二乙烯基苯微球(PS-DVB)。研究了交联剂与致孔剂的加入量对微球形貌、粒径及孔结构参数的影响。结果表明,所得多孔微球球形圆整,库尔特测得平均粒径为5.067~5.520μm,粒径分布窄,D90/D10为1.23~1.56,孔结构可控,并以此多孔微球作为反相色谱填料基质,理论塔板数每米可达6 000~15 000,可以用作高效液相色谱(HPLC)填料。
Monodisperse micron-sized polystyrene microspheres (PS) were prepared by dispersion polymerization. Polystyrene microspheres were used as seeds, dibutyl phthalate as swelling agent, styrene as monomer, and divinyl Phenylbenzene as crosslinking agent and toluene as porogen were used to prepare porous high cross-linked polystyrene-divinylbenzene microspheres (PS-DVB) with narrow particle size distribution by means of seed swelling polymerization. The effects of the amount of crosslinking agent and porogen on microstructure, particle size and pore structure parameters were studied. The results showed that the obtained porous microspheres were round and spherical, the average particle size of Coulter was 5.067 ~ 5.520μm, the particle size distribution was narrow, D90 / D10 was 1.23 ~ 1.56, the pore structure was controllable, Reversed-phase chromatographic packing matrix, theoretical plates per meter up to 6000 ~ 15 000, can be used as high performance liquid chromatography (HPLC) packing.