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目的探讨下体负压晕厥前症状（ＰＳＳ）下事件相关电位（ＥＲＰｓ）的Ｐ３潜时（Ｐ３Ｌ）变化特征，为飞行员加速度性晕厥的医学鉴定提供实验方法和依据。方法用下体负压方法（ＬＢＮＰ）诱发ＰＳＳ，观察ＥＲＰｓ的Ｐ３Ｌ变化特征。结果出现ＰＳＳ时，ＥＲＰｓ的Ｐ３Ｌ由３４３．３５±１４．７２ｍｓ延长至５０６．８７±３７．４４ｍｓ（Ｆ（６，４８）＝１４．９６，Ｐ＜０．０５，ＯＺ电极），相关任务反应时（ＲＴ）由５０８．６５±１１．１３ｍｓ延长至６３１．２５±２９．１６ｍｓ（ｔ＝２．９７，Ｐ＜０．０５），靶刺激反应错误率由（４．００±１．６７）％增加至（４３．３８±３．５４）％（ｔ＝３．０６，Ｐ＜０．０５）。ＰＳＳ后第５ｍｉｎ，Ｐ３Ｌ仍明显高于基线值（Ｐ＜０．０５）。而ＲＴ、错误率与基线值已无显著差异（Ｐ＞０．０５）。结论ＥＲＰｓ的Ｐ３Ｌ结合ＲＴ、错误率等指标对飞行员加速度性晕厥的研究有潜在应用价值。
Objective To investigate the characteristics of P3 latency (P3L) of incident-related potentials (ERPs) in pre-syncope pre-syncope symptoms (PSS), and to provide experimental methods and evidences for the medical identification of pilots with accelerated syncope. Methods PSS was induced by lower body negative pressure (LBNP), and the changes of P3L in ERPs were observed. Results When PSS occurred, the P3L of ERPs was prolonged from 343.35 ± 14.72ms to 506.87 ± 37.44ms (F (6,48) = 14.96, P <0.05, OZ electrode) (RT) was prolonged from 508.65 ± 11.13ms to 631.25 ± 29.16ms (t = 2.97, P <0.05), and the error rate of target stimulation reaction was (4.00 ± 1.67) % To (43.38 ± 3.54)% (t = 3.06, P <0.05). At 5 minutes after PSS, P3L was still significantly higher than the baseline (P <0.05). However, there was no significant difference between RT and error rate (P> 0.05). Conclusion P3L binding ERP, ERP error rate and other indicators of pilots with accelerated syncope have potential applications.