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理想的男性避孕药应该是能够妨碍精子生成或阻断精子的受精能力,但不抑制或改变体内男性激素的生成,对性欲、附属性器官和垂体功能无影响,无毒性或严重的副作用,而且使用方便。尽管很多化合物已用于抑制精子生成,但迄今为止,尚未见到这样一种理想的男性避孕药。本文作者首次证明,非激素类的生物活性物质三羟基丙烷(THP)——是多种动物细胞膜磷脂的重要组成成份,具有选择性和强有力的抗精子生成作用,无任何毒性和内分泌方面的副作用。本实验共用119只大鼠,对照组:睾丸内注射无菌双蒸水,实验组;睾丸内注射双蒸水:THP(3:7V/V)。在注射后的11周,检查组织形态和
An ideal male contraceptive should be capable of hindering sperm production or blocking sperm fertility but not inhibiting or altering the production of male hormones in the body, having no effect on libido, appendage organs and pituitary gland function, non-toxic or severe side effects, and using Convenience. Although many compounds have been used to inhibit spermatogenesis, so far, such an ideal male contraceptive has not been seen. The authors demonstrate for the first time that the non-hormonal bioactive substance, trihydroxypropane (THP), is an important component of a variety of animal cell membrane phospholipids and has a selective and potent anti-sperm-forming effect without any toxicity or endocrine side effect. A total of 119 rats were used in this study. The control group: sterile testis with double distilled water, experimental group; intraperitoneal injection of double distilled water: THP (3: 7V / V). At 11 weeks after injection, histological examination was performed