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β-血小板球蛋白(BTG)和血小板因子4(PF_4)是贮存于血小板α颗粒中的特异性血小板蛋白质,它们在血小板聚集时释放,其血浆浓度升高即反映体内血小板活化。作者对20例非胰岛素依赖型糖尿病(NIDDM)病人(男14、女6,平均年龄52.3±9.5岁),10例胰岛素依赖型糖尿病(IDDM)病人(男6、女4,平均年龄48.8±5.3岁)和30名健康人的 BTG 和 PF_4进行配对研究。糖尿病病人的病程为2个月～24(平均11.2)年;NIDDM 患者有大血管病;IDDM 患者无大血管病,但其中6例有单纯性视网膜病、4例有增殖性视网膜病。
β-thromboglobulin (BTG) and platelet factor 4 (PF_4) are specific platelet proteins that are stored in platelet α-particles and are released upon platelet aggregation. Increased plasma concentrations reflect platelet activation in vivo. The authors randomized 20 patients with NIDDM (male 14, female 6, mean age 52.3 ± 9.5) and 10 IDDM patients (male 6, female 4, mean age 48.8 ± 5.3 Year old) and 30 healthy subjects in BTG and PF_4. The duration of diabetes mellitus patients ranged from 2 months to 24 years (mean 11.2 years). NIDDM patients had macrovascular disease. IDDM patients had no macrovascular disease, but 6 had simple retinopathy and 4 had proliferative retinopathy.