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用牛血清白蛋白复制大鼠肝纤维化 ,静脉注射 3次后 ,给予丙肝康治疗。在不同阶段分别测定下述指标 :腹腔巨噬细胞对葡萄球菌的吞噬功能、Fc及 C3b受体活性、CIC、血 T淋巴细胞计数、脾脏形态、AL T、MAO、肝胶原蛋白及肝组织的病理观察。结果 :肝损伤程度持续加重 ,最终形成肝硬化。在此过程中 ,动物的单核巨噬细胞的吞噬功能持续降低 ,血 T淋巴细胞含量降低 ,脾瘀血肿大 ,白髓及脾小体萎缩 ,CIC增高。丙肝康对上述病变有明显的抑制作用。提示 :IC沉积是牛血清白蛋白所致肝损伤的主要因素 ,在此过程中 ,免疫功能下降阻碍了对 IC的清除 ,加重了肝损伤。丙肝康通过提高机体的免疫功能减轻肝损伤
Rat liver fibrosis was replicated with bovine serum albumin and administered after 3 injections. The following indicators were measured at different stages: phagocytosis of Staphylococci by peritoneal macrophages, Fc and C3b receptor activity, CIC, blood T-lymphocyte counts, spleen morphology, AL T, MAO, liver collagen, and liver tissue Pathological observation. Results: The degree of hepatic injury continued to increase, eventually leading to cirrhosis. During this process, the phagocytic function of mononuclear macrophages in animals continued to decrease, blood T lymphocyte content decreased, splenomegaly hematoma swollen, white pulp and splenic body atrophy, and CIC increased. Hepatitis C has a significant inhibitory effect on these lesions. Tip: IC deposition is the main cause of liver damage caused by bovine serum albumin. During this process, the decrease of immune function hinders the clearance of IC and aggravates liver injury. Hepatitis B is relieved by improving the body’s immune function