气道重建是哮喘的一个重要特征,其病理表现包括气道平滑肌数量增加、黏液腺肥大、细胞外基质成分沉积、网状基底膜增厚和血管生成等。重建程度与哮喘的严重性密切相关,随着病变的发展,哮喘患者肺功能的损失逐渐加重,有时候会出现进行性混合型气流阻塞,这些特点可能反应了哮喘的气道重建。并且广泛重建的患者可能产生对皮质醇治疗耐受。因此 Airway remodeling is an important feature of asthma. Its pathological manifestations include increased number of airway smooth muscle, hypertrophy of mucous glands, deposition of extracellular matrix components, thickening of reticular basement membrane and angiogenesis. The degree of reconstruction is closely related to the severity of asthma. With the development of the lesion, the loss of lung function in asthmatic patients gradually aggravates and progressive mixed airflow obstruction sometimes occurs, which may reflect the airway reconstruction of asthma. And extensively reconstructed patients may develop resistance to cortisol treatment. therefore