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选取55～75岁糖尿病合并高血压患者80人(男41,女39),随机双盲分为培多普利/吲哒帕胺干预组和对照组。为期5年。采用高分辨率的超声仪测定CIMT,同时测定可能的影响因素(年龄、BMI、W/H、SBP、DBP、FPG、HbA1c、TC、TG、HDL、LDL、Hs-CRP、IL-6),采用多元线性逐步回归法分析CIMT与诸影响因素的相关性。结果(1)干预组的CIMT、Hs-CRP、IL-6水平低于对照组。两组间CIMT、Hs-CRP、IL-6存在显著性差异(P≤0.01)。(2)CIMT与年龄、W/H、Hs-CRP相关。结论(1)年龄、肥胖、炎症因子是动脉粥样硬化的主要影响因素。(2)严格的控制血压在正常范围,可延缓颈动脉内膜增厚的进程。(3)培多普利具有抗炎作用,可延缓2型糖尿病和高血压患者的动脉粥样硬化。
A total of 80 patients (male 41, female 39) with diabetes mellitus with hypertension 55 to 75 years old were selected and randomly divided into two groups: the pilradipril / indapamide group and the control group. For 5 years. CIMT was measured with a high-resolution ultrasound system and possible influencing factors (age, BMI, W / H, SBP, DBP, FPG, HbA1c, TC, TG, HDL, LDL, Hs-CRP, IL-6) The correlation between CIMT and various influencing factors was analyzed by multivariate linear stepwise regression. Results (1) The levels of CIMT, Hs-CRP and IL-6 in the intervention group were lower than those in the control group. There were significant differences in CIMT, Hs-CRP and IL-6 between the two groups (P≤0.01). (2) CIMT was related to age, W / H and Hs-CRP. Conclusion (1) Age, obesity and inflammatory factors are the main influential factors of atherosclerosis. (2) strict control of blood pressure in the normal range, can delay the process of carotid intimal thickening. (3) Pendipril has an anti-inflammatory effect, which can delay atherosclerosis in patients with type 2 diabetes mellitus and hypertension.