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【目的】探讨基质金属蛋白酶‐9（MMP‐9）和血管内皮生长因子（VEGF）在子宫腺肌病（AM）患者中的表达水平及意义。【方法】选择A M患者30例（腺肌病组）、子宫肌瘤患者30例（肌瘤组）和健康体检者25例（对照组），采用ELISA检测各组血清MMP‐9、VEGF水平，并分析其意义。【结果】腺肌病组患者血清 MMP‐9、VEGF水平明显高于肌瘤组和对照组，差异均有统计学意义（ P ＜0．05）；腺肌病组血清MMP‐9水平与VEGF水平间呈正相关（ P ＜0．05）。【结论】MMP‐9、VEGF在AM 的发生发展中有重要的协同作用，监测血清MMP‐9、VEGF水平可作为辅助诊断AM的实验室指标。“,”Objective]To explore the clinical significance of detecting the serum levels of matrix metalloproteinases‐9 (MMP‐9) and vascular endothelial growth factor (VEGF) in adenomyosis (AM) patients .[Methods]For this study ,30 AM patients ,30 cases of uterine fibroids and 25 healthy controls were recruited .And the serum levels of MMP‐9 and VEGF levels were detected by enzyme‐linked immunosorbent assay (ELISA) .[Results]The serum levels of MMP‐9 and VEGF were significantly higher in adenomyosis group than those of fibroids and normal groups .And the differences were statistically significant ( P<0 .05 or P<0 .01) .And the serum levels of MMP‐9 and VEGF were positively correlated in adenomyosis group( P<0 .05) .[Conclusion]Both MMP‐9 and VEGF play important synergistic roles in the development of AM .Thus their serum levels may be used as auxiliary diagnostic markers for AM .