论文部分内容阅读
某些药物组成复方可以增强主药的疗效,降低不良反应的发生率,起到协同治疗的作用。但如果不了解复方药物的成分,或使用不当,也会影响疗效或产生不应有的副作用。现仅就我们在处方调配工作中发现的一些问题讨论如下。胃蛋白酶合剂与胃得乐(或胃舒平等)合用的处方是常见的。胃蛋白酶是胃粘膜上皮细胞分泌的一种蛋白质分解酶,在pH为2时其生物活性最高,因此胃蛋白酶合剂中含有稀盐酸以造成酸性环境。但胃得乐为一含有碳酸氢钠、碳酸镁、次硝酸铋等的碱性药物,可破坏酸性环境,使胃蛋白酶的生物活性受到影响。由此看来,如果只注意复方药物中的主要成分和主要作用,而不了解其处方的全部组成及其意义,就
The composition of certain drugs can enhance the efficacy of the main drug, reduce the incidence of adverse reactions, play a synergistic effect. However, if you do not understand the composition of the compound drugs, or improper use, but also affect the efficacy or produce unwanted side effects. Here are just some of the issues we found in the deployment of prescriptions. Prescriptions for the combination of pepsin and Stortolol (or Stomach, etc.) are common. Pepsin is a proteolytic enzyme secreted by epithelial cells of the gastric mucosa. It has the highest bioactivity at a pH of 2 so that the pepsin mixture contains dilute hydrochloric acid to cause an acidic environment. However, Stomach is a sodium bicarbonate, magnesium carbonate, bismuth subnitrate and other alkaline drugs, can damage the acidic environment, so that the biological activity of pepsin affected. From this, it seems that if we only pay attention to the main components and main functions of the compound drugs without knowing the whole composition and meaning of the prescriptions,