已知吸烟是诱发体内活性氧生成的一种来源 ,本研究运用多项生物标志物 ,评价吸烟诱发的氧化应激对ＤＮＡ损伤和修复以及抗氧化防御机制中所涉及的某些途径的影响。本研究吸烟组为 2 1名健康吸烟者 ,对照组为 2 4名终生不吸烟者。两组的平均年龄分别为 39± 2 4岁 (2 4～ 5 4岁 Smoking is known to be a source of reactive oxygen species (ROS) in vivo. In this study, a number of biomarkers were used to evaluate the effects of smoking-induced oxidative stress on some of the pathways involved in DNA damage and repair and antioxidant defense mechanisms. In this study, 21 healthy smokers were enrolled in the smoking group and 24 lifetime non-smokers in the control group. The average age of the two groups were 39 ± 2 4 years (24 to 54 years old