论文部分内容阅读
近年来,有不少研究工作者报道了用化学物质诱导恶性癌细胞进行有限的分化。这类物质主要有维生素A酸(RA),丁酸钠(Na-butyrare),二甲基亚砜(DM-SO),环腺嘌呤核苷酸(c-AMP)以及环六亚甲基双乙酰胺(hexamethylene bisaceta-mide,HMBA)等,它们能使癌细胞恶性表型受到抑制,并向一定类型的体细胞分化。HMBA最早用于研究小鼠红白血病细胞的诱导分化,并为研究珠蛋白基因表达提供了很好的实验模型。随后,Jakob等
In recent years, many researchers reported the limited differentiation of malignant cancer cells induced by chemical substances. Such substances are mainly vitamin A acid (RA), sodium butyrate (Na-butyrare), dimethyl sulfoxide (DM-SO), cyclic adenine nucleotide (c- AMP) and hexamethylene bis (Hexamethylene bisaceta-mide, HMBA), which can inhibit the malignant phenotype of cancer cells and differentiate into certain types of somatic cells. HMBA was first used to study the induced differentiation of murine erythroleukemia cells and provided a good experimental model for the study of globin gene expression. Subsequently, Jakob et al