牙周—牙髓综合征这一术语,1972年首先由 Bender 和 Seltzer 提出,现为许多学者沿用。牙髓和牙周组织都来自中胚层,解剖上除在根尖孔相连外,牙髓的侧支在髓室底和根管的任何部分都可能存在,因此牙髓和牙周组织的交通很多,互相影响的机会也就增多。当边缘性牙周病变向纵深方向发展波及到根尖部时,往往可以发生逆行性牙髓炎, Periodontal - the term pulp syndrome, first proposed by Bender and Seltzer in 1972, is now used by many scholars. Both pulp and periodontal tissue are from the mesoderm. Except for the connective anatomy of the apical foramen, the collateral of the dental pulp may be present in any part of the medullary canal and root canal. As a result, there is much traffic to the pulp and periodontal tissue , Opportunities for mutual influence will increase. When marginal periodontal disease to the depth direction of the development of the root tip, can often occur retrograde pulpitis,