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目的研究硒对氟致机体损伤的保护作用及探讨其保护机理。方法采用现场与实验室相结合方法在人体、动物和细胞水平就硒对高氟所致机体损伤的保护作用及其机理应用多学科先进技术从内外环境微量元素、骨形态结构、非骨相组织病理、自由基及抗氧化酶类、心肌细胞电生理、甲状腺激素等方面进行了研究。结果现场工作中证实山东省存在低硒高氟并存地区 ;硒对氟中毒患者具有排高氟作用 ;硒抗高氟损伤的重要机制为促进尿氟排泄、保护骨骼系统、调整自由基代谢及对肝、肾、心脏的作用。结论一定浓度范围内的硒对高氟具有拮抗作用。
Objective To study the protective effects of selenium on fluoride induced injury and to explore its protective mechanism. Methods The combination of on-site and laboratory methods was used to study the protective effect and mechanism of selenium on organ injury induced by high fluoride in human, animal and cell levels. Using multidisciplinary advanced technologies, the microelements, bone morphological structure, , Free radicals and antioxidant enzymes, cardiomyocyte electrophysiology, thyroid hormone and other aspects were studied. Results Field work confirmed the presence of low-selenium and high fluoride in Shandong Province. Selenium exerted a high fluoride effect on patients with fluorosis. The important mechanism of selenium against high fluoride injury was to promote urinary fluoride excretion, to protect the skeletal system, to regulate free radical metabolism, and to Liver, kidney, heart function. Conclusion Selenium at a certain concentration range has antagonistic effect on high fluoride.