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目前尚无阻止多发性硬化(MS)病情进展和加重的有效治疗方法。有人报道免疫球蛋白能增加重症肌无力患者的 T 抑制细胞数。对MS 也许有相同作用。免疫球蛋白能封闭 MHC-Ⅱ类抗原,该抗原在自身免疫性疾病中频繁表达。病人和方法治疗组为10例反复发作的MS 患者,应用免疫球蛋白治疗,剂量0.4g/kg/d,加入9%～11%麦芽糖中静滴,持续5天。然后以该剂量治疗,每2个月一天,治疗12个月。对照组为10例反复发作的 MS 患者,不给予治疗。两组的年龄、病程及每年发作次数均相配。临床观察随访1年。结果治疗组每年病情急性加剧次数由3.7±1.2减少到1.0±0.7,而对照组则无改变(P<0.001)。Kurtzke EDSS(致残状态评分)示治疗组从平均4.45降到4.15,而对照组则从
There are currently no effective treatments to stop the progression and aggravation of multiple sclerosis (MS). It has been reported that immunoglobulin can increase the number of T suppressor cells in patients with myasthenia gravis. May have the same effect on MS. Immunoglobulins block MHC class II antigens, which are frequently expressed in autoimmune diseases. Patients and Methods The treatment group consisted of 10 recurrent MS patients treated with immunoglobulin at a dose of 0.4 g / kg / day and treated with 9% to 11% maltose for 5 days. Then treated with this dose, one day every 2 months for 12 months. The control group was 10 patients with recurrent MS without treatment. Two groups of age, duration and number of attacks each year are matched. Clinical observation followed up for 1 year. Results The number of acute exacerbations in the treatment group decreased from 3.7 ± 1.2 to 1.0 ± 0.7 per year, but not in the control group (P <0.001). Kurtzke EDSS (disability status score) showed that the treatment group dropped from an average of 4.45 to 4.15 while the control group from