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目的探讨在糖尿病周围神经病变(DPN)患者中运用前列地尔及甲钴胺的治疗价值。方法随机将我院近2年时间治疗的80例DPN病例均分成两个组,对照组40例单纯予甲钴胺用药,观察组40例选择甲钴胺+前列地尔方案治疗,连续用药满3周后,研究两组的病情改善情况。结果观察组用药后的临床总治愈率相比对照组有明显增高,运动神经、感觉神经等各项指标水平也有更明显改善,有统计学意义(P<0.05)。用药期间,两组对象均未出现严重毒性症状。结论选择前列地尔+甲钴胺方案对DPN患者展开治疗,总体疗效更加理想和安全,更利于神经功能的改善,适合加强推广。
Objective To investigate the therapeutic value of using alprostadil and mecobalamin in patients with diabetic peripheral neuropathy (DPN). Methods A total of 80 DPN cases treated in our hospital for 2 years were randomly divided into two groups. 40 cases in the control group were treated with mecobalamin alone, 40 cases in the observation group were treated with mecobalamin and alprostadil, Three weeks later, the condition of the two groups was studied. Results The total clinical cure rate after treatment in the observation group was significantly higher than that in the control group. The levels of motor nerve and sensory nerve were also significantly improved (P <0.05). During the medication, no severe toxicity symptoms were found in both groups. CONCLUSIONS: The prostaglandin + mecobalamin regimen is selected for the treatment of patients with DPN. The overall effect is more ideal and safe, which is more conducive to the improvement of neurological function and is suitable for promotion.